Current Issue : January-March Volume : 2016 Issue Number : 1 Articles : 1 Articles
Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils, surfactants and co-surfactants, which improve dissolution of poorly soluble drugs by rapid self-emulsification. It is estimated that about 40% of active pharmaceutical substances are poorly water soluble. Various strategies are reported including micronization, solid dispersions, complexation and other technologies. Among various approach SEDDS has gained an important attention due to enhanced oral bioavailability, more consistent temporal profiles of drug absorption, targeting of drugs toward specific absorption window and protection of drug from the hostile environment in gut. The important characterization parameters are their globule size and shape, ability to encapsulate the drug, gastrointestinal and thermodynamic stability and rheological characteristics. This review highlights an explicit discussion on important applications of the SEDDS and other important relevant information....
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